题目：Lipidcomposition,Virusreplication,andOvuledevelopment

报告人：王晓峰助理教授（美国VirginiaTechUniversity）

时间：2014年7月25日上午9：00

地点：国家甘蔗产业技术研发中心201学术报告厅

主办：国家甘蔗产业技术研发中心

报告人简介：王晓峰博士2002年毕业于美国密西根州立大学遗传学专业,获博士学位；2002-2007年到美国威斯康辛州大学从事分子病毒学博士后研究；2007-2009年为美国威斯康辛州大学分子病毒研究所助理研究员；2009-2012年为美国得州农工大学助理教授；2012-至今为美国弗吉尼亚理工大学助理教授。王晓峰博士主要从事病毒与植株寄主互作机理研究，在国际著名期刊《PNAS》、《JournalofVirology》等发表了10多篇学术论文。

Researchinterest:

Viralreplicationmechanisms&virus-hostinteractionsofpositive-strandRNAviruses

·InteractionsbetweenhostmembraneandBromemosaicvirus(BMV)replicationinyeastandplants

*HostlipidmetabolismgenesinvolvedintheassemblyandfunctionofBMVRNAreplicationcomplex:acyl-CoAbindingprotein(ACBP)&fattyaciddesaturase

*Hostmultivesicularbody(MVB)pathwayinBMVRNAreplication

·Mechanism-basedantiviralstrategiesinplants:Manipulatinglipidsynthesistocontrolviralreplication

·DevelopmentofBMVasanefficientviralvectorforgenesilencinginmonocotplants

·Cloningandapplicationofvirus-resistancegenesinsoybeanandbarley

Education:

1992：ChinaAgricultureUniversity，PlantGeneticsandBreeding，BS

1995：ChineseAcademyofAgriculturalSciences，PlantGeneticsandBreeding，MS2002：MichiganStateUniversity，Genetics，PhD

2002-07：UniversityofWisconsin&HHMI，MolecularVirology，Post-doc

Professionalappointments:

08/2012–Present:AssistantProfessor,DepartmentofPlantPathology,PhysiologyandWeedScience,VirginiaTechUniversity.

08/2009–07/2012:AssistantProfessor,TexasAgriLifeResearchandDepartmentofPlantPathology&Microbiology,TexasA&MUniversitySystem.

2007–2009:AssistantScientist,InstituteforMolecularVirology,UniversityofWisconsin,Madison.

Selectedpublications:

²HaoL.,LindenbachB.,WangX.,DyeB.,KushnerD.,HeQ.,NewtonM.,andAhlquistP.(2014)Genome-wideanalysisofhostfactorsinNodavirusRNAreplication.PLoSOne9:e95799.doi:10.1371/journal.pone.0095799

²GaoS.J.,Damaj,M.B.,ParkJ.W.,BeyeneG.,Buenrostro-NavaM.T.,MolinaJ.,WangX.,Ciomperlik,J.J.,ManabayevaS.A.,AlvaradoV.,Y.,RathoreK.S.,Scholthof,H.B.,MirkovT.E.(2013)Enhancedtransgeneexpressioninsugarcanebyco-expressionofvirus-encodedRNAsilencingsuppressors,PLoSOne8:e66046.doi:10.1371/journal.pone.0066046

²ZhangJ.,DiazA.,MaoL.,AhlquistP.,andWangX.*(2012)HostacylCoenzymeAbindingproteinregulatesreplicationcomplexassemblyandactivityofapositive-strandRNAvirus.JournalofVirology86:5110-5121,*Correspondingauthor

²WangX.*,DiazA.,HaoL.,GancarzB.,denBoonJ.A.,andAhlquistP.*(2011)IntersectionofthemultivesicularbodypathwayandlipidhomeostasisinRNAreplicationofapositive-strandRNAvirus.JournalofVirology85:5494-5503,*:Co-correspondingauthors(FeaturedinSPOTLIGHT)

²DiazA.,WangX.,andAhlquistP.(2010)Membrane-shapinghostreticulonproteinsplaycrucialrolesinviralRNAreplicationcompartmentformationandfunction.Proc.Natl.Acad.Sci.USA107:16291-16296

²LiuL.,WestlerW.M.,denBoonJ.A.,WangX.,DiazA.,SteinbergH.A.,andAhlquistP.(2009)Anamphipathica-helixcontrolsmultiplerolesofbromemosaicvirusprotein1ainRNAreplicationcomplexassemblyandfunction.PLoSPathogen5:e1000351

²Wang,X.,andAhlquistP.(2008)FillingaGAP(DH)inasymmetricviralRNAsynthesis.CellHost&Microbe.3:124-125

²Wang,X.,andAhlquistP.(2008)Bromemosaicvirus(Bromoviridae).In:EncyclopediaofVirology(B.W.J.MahyandM.H.V.vanRegenmortel,eds),ThirdEdition,pp.381-386,Elservier,Oxford,UnitedKingdom

²Wang,X.,Lee,W.M.,Watanabe,T.,Schwartz,M.,Janda,M.,andAhlquist,P.(2005)Bromemosaicvirus1anucleosidetriphosphatase/helicasedomainplayscrucialrolesinrecruitingRNAreplicationtemplates.JournalofVirology79:13747-13758(FeaturedinSPOTLIGHT)